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Study on molybdenum adsorption properties of alumina-based adsorbents and their application to $^{99}$ Mo/ $^{rm 99m}$ Tc generators using the (n,) method (Thesis)

Fujita, Yoshitaka

JAEA-Review 2023-010, 108 Pages, 2023/08

JAEA-Review-2023-010.pdf:6.62MB

$^{rm 99m}$ Tc (technetium-99m) is the most widely used radioisotope in radiopharmaceutical and is decayed from the parent nuclide $^{99}$ Mo (molybdenum-99). Most of $^{99}$ Mo is generated as one of the fission products of uranium, but recently, from the viewpoint of nuclear security and nuclear nonproliferation, a uranium-free $^{99}$ Mo production method is desired. One such method is the (n,) method, in which $^{98}$ Mo is irradiated by neutrons. However, since the specific activity of $^{99}$ Mo produced by this method is extremely low, it is necessary to improve the Mo adsorption and $^{rm 99m}$ Tc elution property of alumina (Al $_{2}$ O $_{3}$ ), which is used as a Mo adsorbent, to apply this method to the $^{99}$ Mo/ $^{rm 99m}$ Tc generator, a device for separation and concentration of $^{rm 99m}$ Tc from $^{99}$ Mo. Therefore, the objective of this thesis is to elucidate the parameters effective for improving the performance of alumina for the practical use of the $^{99}$ Mo/ $^{rm 99m}$ Tc generator using the (n,) method, and to contribute to the development of alumina columns that may be applicable to low specific activity $^{99}$ Mo. In this study, alumina with different starting materials was prepared and its applicability as Mo adsorbent for $^{99}$ Mo/ $^{rm 99m}$ Tc generator was evaluated. The effects of crystal structure and specific surface area of alumina on Mo adsorption properties were clarified, and the Mo adsorption mechanism was elucidated based on the results of surface analysis of alumina. In addition, $^{rm 99m}$ Tc elution properties and $^{rm 99m}$ Tc solution quality were evaluated using MoO $_{3}$ irradiated in the Kyoto University Research Reactor (KUR), and a new column shape with potential application to generators was proposed based on the experiment results of alumina columns designed for current generators.

Journal Articles

Study on $^{rm 99m}$ Tc separation/concentration technology from $^{99}$ Mo by (n, ) method

Fujita, Yoshitaka; Hu, X.*; Takeuchi, Tomoaki; Takeda, Ryoma; Fujihara, Yasuyuki*; Yoshinaga, Hisao*; Hori, Junichi*; Suzuki, Tatsuya*; Suematsu, Hisayuki*; Ide, Hiroshi

KURNS Progress Report 2022, P. 110, 2023/07

https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2022/ProgressReport2022.pdf#page=125

no abstracts in English

Journal Articles

Radiochemical research for the advancement of $^{99}$ Mo/ $^{rm 99m}$ Tc generator by (n, ) method, 4

Fujita, Yoshitaka; Seki, Misaki; Ngo, M. C.*; Do, T. M. D.*; Hu, X.*; Yang, Y.*; Takeuchi, Tomoaki; Nakano, Hiroko; Fujihara, Yasuyuki*; Yoshinaga, Hisao*; et al.

KURNS Progress Report 2021, P. 118, 2022/07

https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2021/ProgressReport2021_online.pdf#page=134

no abstracts in English

JAEA Reports

Development of fundamental technologies for domestic production of medical radioisotope (technetium-99m); The First and second phase report (FY2014-2020)

Project 6 Meeting Members for Tsukuba International Strategic Zone

JAEA-Review 2021-016, 102 Pages, 2021/11

JAEA-Review-2021-016.pdf:12.76MB

In December 2011, the Prime Minister designated Tsukuba and some areas in Ibaraki Prefecture as "Comprehensive Special Zones". In the Tsukuba International Strategic Zone, nine advanced research and development (R&D) projects are underway with the goal of promoting industrialization of life innovation and green innovation utilizing the science and technology in Tsukuba. In these projects, the domestic production of medical radioisotope (Technetium-99m, $^{rm 99m}$ Tc) was certified as a new project in October 2013, and R&D have been performed in collaboration with related organizations with Japan Atomic Energy Agency (JAEA) as the project leader. Japan is the third largest consumer of molybdenum-99 ( $^{99}$ Mo) after the United States and Europe, and all $^{99}$ Mo are imported. Supply will be insufficient if overseas reactors are shut down due to trouble or if transportation (air and land transportations) is stopped due to volcanic eruptions and some accidents. Thus, early domestic production of $^{99}$ Mo is strongly required. This project is a technology development aimed at domestic production of $^{99}$ Mo, which is a raw material of $^{rm 99m}$ Tc used as a diagnostic agent. This report summarizes the activities carried out in the first and second phase of the domestic production of medical radioisotope ( $^{rm 99m}$ Tc) (here referred to as the "Project 6") in Tsukuba International Strategic Zone (FY2014-2020).

Journal Articles

Radiochemical research for the advancement of $^{99}$ Mo/ $^{rm 99m}$ Tc generator by (n,) method, 2

Fujita, Yoshitaka; Seki, Misaki; Namekawa, Yoji*; Nishikata, Kaori; Kato, Yoshiaki; Sayato, Natsuki; Tsuchiya, Kunihiko; Sano, Tadafumi*; Fujihara, Yasuyuki*; Hori, Junichi*; et al.

KURNS Progress Report 2019, P. 157, 2020/08

https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2019/ProgressReport2019_online.pdf#page=173

no abstracts in English

Journal Articles

Radiochemical research for the advancement of $^{99}$ Mo/ $^{rm 99m}$ Tc generator by (n,) method

Fujita, Yoshitaka; Seki, Misaki; Namekawa, Yoji*; Nishikata, Kaori; Kimura, Akihiro; Shibata, Akira; Sayato, Natsuki; Tsuchiya, Kunihiko; Sano, Tadafumi*; Fujihara, Yasuyuki*; et al.

KURNS Progress Report 2018, P. 155, 2019/08

https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2018/KURNS_Progress_Report2018_web.pdf

no abstracts in English

Journal Articles

Development of novel alumina adsorbent applying mesoporous process

Fukumitsu, Nobuyoshi*; Yamauchi, Yusuke*; Saptiama, I.*; Ariga, Katsuhiko*; Hatano, Kentaro*; Kumada, Hiroaki*; Fujita, Yoshitaka; Tsuchiya, Kunihiko

Isotope News, (760), p.15 - 18, 2018/12

no abstracts in English

Journal Articles

Neutron irradiation effect of high-density MoO $_{3}$ pellets for Mo-99 production

Fujita, Yoshitaka; Nishikata, Kaori; Namekawa, Yoji*; Kimura, Akihiro; Shibata, Akira; Sayato, Natsuki; Tsuchiya, Kunihiko; Sano, Tadafumi*; Fujihara, Yasuyuki*; Zhang, J.*

KURRI Progress Report 2017, P. 126, 2018/08

http://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2017/Progress_Report2017_web.pdf#page=139

no abstracts in English

Journal Articles

Neutron irradiation effect of high-density MoO $_{3}$ pellets for Mo-99 production, 3

Ishida, Takuya; Suzuki, Yoshitaka; Nishikata, Kaori; Yonekawa, Minoru; Kato, Yoshiaki; Shibata, Akira; Kimura, Akihiro; Matsui, Yoshinori; Tsuchiya, Kunihiko; Sano, Tadafumi*; et al.

KURRI Progress Report 2015, P. 64, 2016/08

http://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2015/PR2015.pdf#page=73

no abstracts in English

Oral presentation

Development of irradiation targets for $^{99}$ Mo/ $^{99m}$ Tc production by activation method

Tsuchiya, Kunihiko; Nishikata, Kaori; Kimura, Akihiro; Ishida, Takuya; Takeuchi, Nobuhiro*; Kobayashi, Masaaki*; Kawamura, Hiroshi

no journal, ,

no abstracts in English

Oral presentation

Status of domestic production of medical radioisotope (technetium-99m) in Japan

Tsuchiya, Kunihiko

no journal, ,

no abstracts in English

Oral presentation

Supply of $^{99}$ Mo; Production in research reactors

Tsuchiya, Kunihiko

no journal, ,

no abstracts in English

Oral presentation

Nuclide separation by water for development of $^{99}$ Mo/ $^{99m}$ Tc generator for medical

Seki, Misaki*; Suematsu, Hisayuki*; Nakayama, Tadachika*; Suzuki, Tsuneo*; Niihara, Koichi*; Suzuki, Tatsuya*; Tsuchiya, Kunihiko; Duong Van, D.*

no journal, ,

no abstracts in English

Oral presentation

Domestic production of medical radioisotope (technetium-99m)

Tsuchiya, Kunihiko

no journal, ,

no abstracts in English

Oral presentation

Research and development of $^{99}$ Mo/ $^{99m}$ Tc production process by (n,) method

Tsuchiya, Kunihiko; Shibata, Tokushi*; Uno, Tsuyoshi*; Hasegawa, Yoshio*; Kakei, Sadanori*; Fukumitsu, Nobuyoshi*; Kusunoki, Tsuyoshi; Kaminaga, Masanori

no journal, ,

no abstracts in English

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Study on molybdenum adsorption properties of alumina-based adsorbents and their application to $^{99}$ Mo/ $^{rm 99m}$ Tc generators using the (n,) method (Thesis)

Study on $^{rm 99m}$ Tc separation/concentration technology from $^{99}$ Mo by (n, ) method

Radiochemical research for the advancement of $^{99}$ Mo/ $^{rm 99m}$ Tc generator by (n, ) method, 4

Development of fundamental technologies for domestic production of medical radioisotope (technetium-99m); The First and second phase report (FY2014-2020)

Radiochemical research for the advancement of $^{99}$ Mo/ $^{rm 99m}$ Tc generator by (n,) method, 2

Radiochemical research for the advancement of $^{99}$ Mo/ $^{rm 99m}$ Tc generator by (n,) method

Development of novel alumina adsorbent applying mesoporous process

Neutron irradiation effect of high-density MoO $_{3}$ pellets for Mo-99 production

Neutron irradiation effect of high-density MoO $_{3}$ pellets for Mo-99 production, 3

Development of irradiation targets for $^{99}$ Mo/ $^{99m}$ Tc production by activation method

Status of domestic production of medical radioisotope (technetium-99m) in Japan

Supply of $^{99}$ Mo; Production in research reactors

Nuclide separation by water for development of $^{99}$ Mo/ $^{99m}$ Tc generator for medical

Domestic production of medical radioisotope (technetium-99m)

Research and development of $^{99}$ Mo/ $^{99m}$ Tc production process by (n,) method